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  2. HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the on...

    Authors: Maggie L Bobbin, John C Burnett and John J Rossi
    Citation: Genome Medicine 2015 7:50
    Content type: Review Published on:

  3. Lymphocyte receptor repertoires are continually shaped throughout the lifetime of an individual in response to environmental and pathogenic exposure. Thus, they may serve as a fingerprint of an individual’s on...

    Authors: Victor Greiff, Pooja Bhat, Skylar C. Cook, Ulrike Menzel, Wenjing Kang and Sai T. Reddy
    Citation: Genome Medicine 2015 7:49
    Content type: Research Published on:

  4. Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequenci...

    Authors: Francesc Coll, Ruth McNerney, Mark D Preston, José Afonso Guerra-Assunção, Andrew Warry, Grant Hill-Cawthorne, Kim Mallard, Mridul Nair, Anabela Miranda, Adriana Alves, João Perdigão, Miguel Viveiros, Isabel Portugal, Zahra Hasan, Rumina Hasan, Judith R Glynn…
    Citation: Genome Medicine 2015 7:51
    Content type: Method Published on:

  5. There are many challenges and opportunities for Africans in the emerging area of genome medicine. In particular, there is a need for investment in local education using real-world African genetic data sets. Cl...

    Authors: Geoffrey H Siwo, Scott M Williams and Jason H Moore
    Citation: Genome Medicine 2015 7:47
    Content type: Comment Published on:

    The Erratum to this article has been published in Genome Medicine 2015 7:70

  6. Mesenchymal stem cells (MSCs) are promising candidates for cellular therapies ranging from tissue repair in regenerative medicine to immunomodulation in graft versus host disease after allogeneic transplantati...

    Authors: Gerrit Erdmann, Michael Suchanek, Patrick Horn, Fabian Graf, Christian Volz, Thomas Horn, Xian Zhang, Wolfgang Wagner, Anthony D. Ho and Michael Boutros
    Citation: Genome Medicine 2015 7:46
    Content type: Method Published on:

  8. Inflammatory bowel disease (IBD) is a complex multi-factorial inflammatory disease with Crohn’s disease (CD) and ulcerative colitis (UC) being the two most common forms. A number of transcriptional profiling s...

    Authors: Aashiq H Mirza, Claus HB Berthelsen, Stefan E Seemann, Xiaoyong Pan, Klaus S Frederiksen, Mogens Vilien, Jan Gorodkin and Flemming Pociot
    Citation: Genome Medicine 2015 7:39
    Content type: Research Published on:

  10. This is an Erratum to Genome Medicine 2013, 5:89, highlighting an error in Table 1 of the original article. Please see related article:

    Authors: Reuben J Pengelly, Jane Gibson, Gaia Andreoletti, Andrew Collins, Christopher J Mattocks and Sarah Ennis
    Citation: Genome Medicine 2015 7:44
    Content type: Erratum Published on:

    The original article was published in Genome Medicine 2013 5:89

  11. The overwhelming majority (approximately 80%) of individuals with classic familial adenomatous polyposis (FAP) exhibit mutations in the coding sequence of the adenomatous polyposis coli (APC) tumor suppressor gen...

    Authors: Yiing Lin, Shin Lin, Melanie D Baxter, Lawrence Lin, Susan M Kennedy, Zhengyan Zhang, Paul J Goodfellow, William C Chapman and Nicholas O Davidson
    Citation: Genome Medicine 2015 7:42
    Content type: Research Published on:

  13. Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work ha...

    Authors: Song Ling Poon, Mi Ni Huang, Yang Choo, John R McPherson, Willie Yu, Hong Lee Heng, Anna Gan, Swe Swe Myint, Ee Yan Siew, Lian Dee Ler, Lay Guat Ng, Wen-Hui Weng, Cheng-Keng Chuang, John SP Yuen, See-Tong Pang, Patrick Tan…
    Citation: Genome Medicine 2015 7:38
    Content type: Research Published on:

  15. Periodontitis is a polymicrobial biofilm-induced inflammatory disease that affects 743 million people worldwide. The current model to explain periodontitis progression proposes that changes in the relative abu...

    Authors: Susan Yost, Ana E Duran-Pinedo, Ricardo Teles, Keerthana Krishnan and Jorge Frias-Lopez
    Citation: Genome Medicine 2015 7:27
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2015 7:111

  16. There has been considerable progress in the management of acute lymphoblastic leukemia (ALL) but further improvement is needed to increase long-term survival. The thiopurine agent 6-mercaptopurine (6-MP) used ...

    Authors: Laurent Chouchana, Ana Aurora Fernández-Ramos, Florent Dumont, Catherine Marchetti, Irène Ceballos-Picot, Philippe Beaune, David Gurwitz and Marie-Anne Loriot
    Citation: Genome Medicine 2015 7:37
    Content type: Research Published on:

  17. Heritable bleeding and platelet disorders (BPD) are heterogeneous and frequently have an unknown genetic basis. The BRIDGE-BPD study aims to discover new causal genes for BPD by high throughput sequencing usin...

    Authors: Sarah K Westbury, Ernest Turro, Daniel Greene, Claire Lentaigne, Anne M Kelly, Tadbir K Bariana, Ilenia Simeoni, Xavier Pillois, Antony Attwood, Steve Austin, Sjoert BG Jansen, Tamam Bakchoul, Abi Crisp-Hihn, Wendy N Erber, Rémi Favier, Nicola Foad…
    Citation: Genome Medicine 2015 7:36
    Content type: Research Published on:

  18. All cells in an individual are related to one another by a bifurcating lineage tree, in which each node is an ancestral cell that divided into two, each branch connects two nodes, and the root is the zygote. W...

    Authors: Ziming Weng, Noah Spies, Shirley X Zhu, Daniel E Newburger, Dorna Kashef-Haghighi, Serafim Batzoglou, Arend Sidow and Robert B West
    Citation: Genome Medicine 2015 7:28
    Content type: Research Published on:

  19. Preimplantation genetic diagnosis (PGD) enables profiling of embryos for genetic disorders prior to implantation. The majority of PGD testing is restricted in the scope of variants assayed or by the availabili...

    Authors: Akash Kumar, Allison Ryan, Jacob O Kitzman, Nina Wemmer, Matthew W Snyder, Styrmir Sigurjonsson, Choli Lee, Milena Banjevic, Paul W Zarutskie, Alexandra P Lewis, Jay Shendure and Matthew Rabinowitz
    Citation: Genome Medicine 2015 7:35
    Content type: Research Published on:

  20. Applying genomics to patient care demands sensitive, unambiguous and rapid characterization of a known set of clinically relevant variants in patients’ samples, an objective substantially different from the st...

    Authors: Wanding Zhou, Hao Zhao, Zechen Chong, Routbort J Mark, Agda K Eterovic, Funda Meric-Bernstam and Ken Chen
    Citation: Genome Medicine 2015 7:34
    Content type: Method Published on:

  21. With the prevalence of cardio-metabolic disorders reaching pandemic proportions, the search for modifiable causative factors has intensified. One such potential factor is the vast microbial community inhabitin...

    Authors: Tue H Hansen, Rikke J Gøbel, Torben Hansen and Oluf Pedersen
    Citation: Genome Medicine 2015 7:33
    Content type: Review Published on:

  22. Three-dimensional organotypic culture models show great promise as a tool for cancer precision medicine, with potential applications for oncogene modeling, gene discovery and chemosensitivity studies.

    Authors: Michael A Cantrell and Calvin J Kuo
    Citation: Genome Medicine 2015 7:32
    Content type: Comment Published on:

  23. Most pediatric tumors have only very few somatic mutations. However, a recent study revealed that a subset of tumors from children with congenital biallelic deficiency of DNA mismatch repair exhibits a mutatio...

    Authors: Matthias Schlesner and Roland Eils
    Citation: Genome Medicine 2015 7:31
    Content type: Research highlight Published on:

  24. RNA-sequencing (RNA-seq) is a powerful technique for the identification of genetic variants that affect gene-expression levels, either through expression quantitative trait locus (eQTL) mapping or through alle...

    Authors: Patrick Deelen, Daria V Zhernakova, Mark de Haan, Marijke van der Sijde, Marc Jan Bonder, Juha Karjalainen, K Joeri van der Velde, Kristin M Abbott, Jingyuan Fu, Cisca Wijmenga, Richard J Sinke, Morris A Swertz and Lude Franke
    Citation: Genome Medicine 2015 7:30
    Content type: Research Published on:

  25. Recent twin studies highlight the astonishing impact of non-heritable contributions to our immune health and wellbeing. Immunologists, long familiar with heterogeneity generated from within cells, must now gra...

    Authors: Alan G Baxter and Philip D Hodgkin
    Citation: Genome Medicine 2015 7:29
    Content type: Research highlight Published on:

  26. Human leukocyte antigen (HLA) typing from next generation sequencing (NGS) data has the potential for widespread applications. Here we introduce a novel tool (HLAreporter) for HLA typing from NGS data based on...

    Authors: Yazhi Huang, Jing Yang, Dingge Ying, Yan Zhang, Vorasuk Shotelersuk, Nattiya Hirankarn, Pak Chung Sham, Yu Lung Lau and Wanling Yang
    Citation: Genome Medicine 2015 7:25
    Content type: Method Published on:

  27. Heart failure (HF) is the most common cause of morbidity and mortality in developed countries. Here, we identify biologically relevant transcripts that are significantly altered in the early phase of myocardia...

    Authors: Agata Maciejak, Marek Kiliszek, Marcin Michalak, Dorota Tulacz, Grzegorz Opolski, Krzysztof Matlak, Slawomir Dobrzycki, Agnieszka Segiet, Monika Gora and Beata Burzynska
    Citation: Genome Medicine 2015 7:26
    Content type: Research Published on:

  29. Urothelial carcinoma of the bladder (UC) is a common malignancy. Although extensive transcriptome analysis has provided insights into the gene expression patterns of this tumor type, the mechanistic underpinni...

    Authors: Mattias Aine, Gottfrid Sjödahl, Pontus Eriksson, Srinivas Veerla, David Lindgren, Markus Ringnér and Mattias Höglund
    Citation: Genome Medicine 2015 7:23
    Content type: Research Published on:

  30. Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every human cancer. Compared to protein-coding genes, lncRNA gene...

    Authors: Ewan A Gibb, René L Warren, Gavin W Wilson, Scott D Brown, Gordon A Robertson, Gregg B Morin and Robert A Holt
    Citation: Genome Medicine 2015 7:22
    Content type: Research Published on:

  31. During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and orga...

    Authors: Karell G Pelle, Keunyoung Oh, Kathrin Buchholz, Vagheesh Narasimhan, Regina Joice, Danny A Milner, Nicolas MB Brancucci, Siyuan Ma, Till S Voss, Ken Ketman, Karl B Seydel, Terrie E Taylor, Natasha S Barteneva, Curtis Huttenhower and Matthias Marti
    Citation: Genome Medicine 2015 7:19
    Content type: Research Published on:

  32. Microbiome-based therapies are moving quickly towards the clinic, with successes including fecal microbial transplants for recurring Clostridium difficile, hints of new antibiotics to come, and possible new micro...

    Authors: Fergus Shanahan
    Citation: Genome Medicine 2015 7:17
    Content type: Comment Published on:

  35. The editors of Genome Medicine are extremely grateful for the time, hard work and support of all our reviewers, and would like to thank everyone who contributed to the journal in Volume 6 (2014).

    Authors: Rebecca Furlong
    Citation: Genome Medicine 2015 7:14
    Content type: Reviewer acknowledgement Published on:

  37. The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a functio...

    Authors: Taotao Lao, Kimberly Glass, Weiliang Qiu, Francesca Polverino, Kushagra Gupta, Jarrett Morrow, John Dominic Mancini, Linh Vuong, Mark A Perrella, Craig P Hersh, Caroline A Owen, John Quackenbush, Guo-Cheng Yuan, Edwin K Silverman and Xiaobo Zhou
    Citation: Genome Medicine 2015 7:12
    Content type: Research Published on:

  38. The role played by microRNAs in the deregulation of protein expression in breast cancer is only partly understood. To gain insight, the combined effect of microRNA and mRNA expression on protein expression was...

    Authors: Miriam Ragle Aure, Sandra Jernström, Marit Krohn, Hans Kristian Moen Vollan, Eldri U Due, Einar Rødland, Rolf Kåresen, Prahlad Ram, Yiling Lu, Gordon B Mills, Kristine Kleivi Sahlberg, Anne-Lise Børresen-Dale, Ole Christian Lingjærde and Vessela N Kristensen
    Citation: Genome Medicine 2015 7:21
    Content type: Research Published on:

  39. Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is imperfect for predicting outcome, which results in overtreatment for many patie...

    Authors: Lao H Saal, Johan Vallon-Christersson, Jari Häkkinen, Cecilia Hegardt, Dorthe Grabau, Christof Winter, Christian Brueffer, Man-Hung Eric Tang, Christel Reuterswärd, Ralph Schulz, Anna Karlsson, Anna Ehinger, Janne Malina, Jonas Manjer, Martin Malmberg, Christer Larsson…
    Citation: Genome Medicine 2015 7:20
    Content type: Research Published on:

  41. Wilms tumours (WTs) are characterised by several hallmarks that suggest epimutations such as aberrant DNA methylation are involved in tumour progression: loss of imprinting at 11p15, lack of recurrent mutation...

    Authors: Jocelyn Charlton, Richard D Williams, Neil J Sebire, Sergey Popov, Gordan Vujanic, Tasnim Chagtai, Marisa Alcaide-German, Tiffany Morris, Lee M Butcher, Paul Guilhamon, Stephan Beck and Kathy Pritchard-Jones
    Citation: Genome Medicine 2015 7:11
    Content type: Research Published on:

  42. Studies examining whether genetic risk information about common, complex diseases can motivate individuals to improve health behaviors and advance planning have shown mixed results. Examining the influence of ...

    Authors: Kurt D Christensen, J Scott Roberts, Brian J Zikmund-Fisher, Sharon LR Kardia, Colleen M McBride, Erin Linnenbringer and Robert C Green
    Citation: Genome Medicine 2015 7:10
    Content type: Research Published on:

  43. The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine...

    Authors: Laurianne Scourzic, Enguerran Mouly and Olivier A Bernard
    Citation: Genome Medicine 2015 7:9
    Content type: Review Published on:

  46. Human cancers are frequently polyploid, containing multiple aneuploid subpopulations that differ in total DNA content. In this study we exploit this property to reconstruct evolutionary histories, by assuming ...

    Authors: Ankit Malhotra, Yong Wang, Jill Waters, Ken Chen, Funda Meric-Bernstam, Ira M Hall and Nicholas E Navin
    Citation: Genome Medicine 2015 7:6
    Content type: Method Published on:

  47. With the advent of affordable and comprehensive sequencing technologies, access to molecular genetics for clinical diagnostics and research applications is increasing. However, variant interpretation remains c...

    Authors: Dace Ruklisa, James S Ware, Roddy Walsh, David J Balding and Stuart A Cook
    Citation: Genome Medicine 2015 7:5
    Content type: Research Published on:

  49. Failure to consider lessons from behavioral economics in the case of whole genome sequencing may cause us to run into the ‘last mile problem’ - the failure to integrate newly developed technology, on which bil...

    Authors: Jennifer S Blumenthal-Barby, Amy L McGuire, Robert C Green and Peter A Ubel
    Citation: Genome Medicine 2015 7:3
    Content type: Comment Published on:
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Genome Medicine

ISSN: 1756-994X

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