Fig. 3
From: Identifying latent genetic interactions in genome-wide association studies using multiple traits
A comparison of aLIT (black) to a marginal testing procedure using the squared residuals (SQ; light gray) and a marginal testing procedure using the squared residuals and cross products (SQ/CP; dark gray) under A positive pleiotropy and B a mixture of positive and negative pleiotropy. The simulation study is identical to Fig. 2 where the empirical power is calculated as a function of the proportion of traits with an interaction term (x-axis), the number of traits (rows), and trait correlation (columns)