Fig. 4

The landscape of copy number variation in NKTCL. A Distribution of different categories of CNVs across the 163 NKTCL patients. The CNV categories employed here include single CN loss (CN = 1 copy), double CN loss (CN = 0), low-level CN gain (CN = 3), and high-level CN gain (CN > 3 copies). B Heatmap of CNVs in patients with primary and relapsed/refractory NKTCL. C The per-sample CNV number comparison between the primary and the relapsed/refractory groups. Brunner–Munzel test was applied for assessing the statistical significance. D The per-sample aneuploidy score comparison between the primary and the relapsed/refractory groups. Brunner–Munzel test was applied for assessing the statistical significance. E KEGG pathway enrichment analysis of gene-level CNVs for patients with NKTCL. F Gene-level CNV landscape across the 163 NKTCL patients