Fig. 2

Mutational signatures operating in NKTCL. A Major SBS signatures (SBS1, 5, 6) identified from the 163 NKTCL patients. B Major INDEL signature (ID8) identified from the 163 NKTCL patients. C Proportions of mutations bearing the SBS6 and ID8 signatures in the primary and relapsed/refractory groups respectively. Brunner–Munzel test was applied for assessing the statistical significance