Fig. 3

IDH1 gene activities after AR knockout simulations show significant race-specific differences in prostate tumors. AUC before inhibition (WT), AUC after AR inhibition (KO), and the percent change in AUC between the two conditions in the Nutrient pathway are represented in the heatmap. A Roswell Park (RP) clinical samples, B TCGA clinical samples. C–D Percent change in IDH1 AUC (highlighted in red) was significantly different between prostate tumors from AA and EA men in both C RP and D TCGA clinical samples. Changes in AUC are represented by blue (down) and red (up)