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Fig. 2 | Genome Medicine

Fig. 2

From: Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

Fig. 2

Transcriptomic adaptation of GBM-educated TME subpopulations in PDOXs. A Differentially expressed genes (DEGs) between the TME of PDOX and GL261 versus corresponding normal brains in identified cell types (FDR ≤ 0.01, |log2FC|≥ 1, Wilcoxon rank sum test with Benjamini–Hochberg correction). B Top four gene ontology terms characterizing DEGs in PDOX versus Nu-NB. C Gene expression levels of exemplary DEGs for distinct cell types in four biological groups: nude mouse brain (Nu-NB), PDOXs (9 models combined), C57BL6/N mouse normal brain (BL6-NB), GL261 tumor (3 time points combined). D Expression levels of exemplary markers in distinct cell types detected and annotated in human GBM tumors by Darmanis et al. [35]

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Genome Medicine

ISSN: 1756-994X

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