Fig. 3

Methylation signature activity associated with disease outcome. A Survival analysis for patients with different DNA methylation signatures was conducted for the individual cancer types in which the corresponding signatures were present. Patients were stratified into two groups based on median signature activity. B Relationships between cancer stage and the activity of methylation signatures in individual cancer types, where the corresponding methylation signatures are present. Patients were stratified into two groups according to tumor stage (stage I, II: pri.; stage III, IV: adv.)