Eligibility criteria | Index cases (number / percent)d |
---|---|
An index case in a family that fulfils clinical criteria for a hereditary cancer syndrome | 28 (14.4) |
An index case with two primary cancers (either synchronous or metachronous) diagnosed at 60 years or younger | 83 (42.6) |
An index case with three primary cancers diagnosed at 70 years or younger | 52 (26.7) |
Index case with colorectal polyposis defined as per InSiGHTa or eviQb testing guidelines for MUTYH and/or APC | 29 (14.9) |
A cancer-affected individual fulfilling two or more of the following criteria: • Early age at onset (under 40 years for adult cancer or < 10 years younger than the mean age of cancer diagnosis for that tumour type and sexc) • One or more first-degree relatives with the same kind of cancer • Two or more first- or second-degree relatives with different cancers, where at least one cancer is very rare | 42 (21.5) |