Fig. 3

Violin plots showing a comparison of the number of single-nucleotide variants (SNVs) in whole genome sequencing from laser capture microdissections of human liver from patients with normal liver (n = 5), alcohol-related liver disease (ARLD) (n = 10) or non-alcoholic fatty liver disease (NAFLD) (n = 19), at A control and B oleic acid peak regions. The median number of SNVs are annotated on the plots. C Stratification of human liver disease cohort by Kleiner fibrosis classification. Significantly more base substitutions are present at oleic acid than control peak regions in patients at each stage of fibrosis (p < 0.001, Wilcoxon rank-sum test), with most SNVs in both groups in Kleiner score 4 livers