Table 2 Results for pathway analysis for the MWAS on PRS at pT 5 × 10⁻⁸. Analyses were conducted separately for including and excluding the MHC region. Top ten Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways are listed in the table

With MHC region

path:hsa05322

Systemic lupus erythematosus

112

1.5

0.093896415

1

path:hsa04914

Progesterone-mediated oocyte maturation

88

1

0.10085395

1

path:hsa04110

Cell cycle

123

1

0.110965189

1

path:hsa04217

Necroptosis

147

1

0.116705111

1

path:hsa04114

Oocyte meiosis

117

1

0.118584815

1

path:hsa04925

Aldosterone synthesis and secretion

95

1

0.137824504

1

path:hsa04613

Neutrophil extracellular trap formation

159

1.5

0.148531242

1

path:hsa04514

Cell adhesion molecules

136

1

0.156764027

1

path:hsa04723

Retrograde endocannabinoid signalling

134

1

0.157693357

1

path:hsa05034

Alcoholism

163

1.5

0.162889755

1

Without MHC region

path:hsa04914

Progesterone-mediated oocyte maturation

88

1

0.077051

1

path:hsa04110

Cell cycle

123

1

0.079099

1

path:hsa04114

Oocyte meiosis

116

1

0.082834

1

path:hsa04514

Cell adhesion molecules

118

1

0.098456

1

path:hsa04925

Aldosterone synthesis and secretion

92

1

0.104019

1

path:hsa04723

Retrograde endocannabinoid signalling

133

1

0.113819

1

path:hsa05203

Viral carcinogenesis

152

1

0.127128

1

path:hsa05166

Human T-cell leukaemia virus 1 infection

193

1

0.1555

1

path:hsa04662

B cell receptor signalling pathway

76

0

1

1

path:hsa05224

Breast cancer

143

0

1

1