Table 1 Results for gene ontology (GO) analysis for the MWAS on PRS at pT 5 × 10⁻⁸. Analyses were conducted separately for including and excluding the MHC region. Top ten GO terms are listed in the table. BP=biological process, CC=cellular component and MF=molecular function

With MHC region

GO:0072643

BP

Interferon-gamma secretion

22

2

2.24E−04

1

GO:0003050

BP

Regulation of systemic arterial blood pressure by atrial natriuretic peptide

2

1

2.64E−03

1

GO:0021691

BP

Cerebellar Purkinje cell layer maturation

2

1

3.27E−03

1

GO:0021590

BP

Cerebellum maturation

3

1

3.64E−03

1

GO:0021699

BP

Cerebellar cortex maturation

3

1

3.64E−03

1

GO:1902412

BP

Regulation of mitotic cytokinesis

6

1

3.88E−03

1

GO:0032609

BP

Interferon-gamma production

105

2

4.06E−03

1

GO:0072686

CC

Mitotic spindle

103

2

4.94E−03

1

GO:0046340

BP

Diacylglycerol catabolic process

4

1

5.24E−03

1

GO:0048408

MF

Epidermal growth factor binding

4

1

5.99E−03

1

Without MHC region

GO:0072686

CC

Mitotic spindle

101

2

2.14E−03

1

GO:0003050

BP

Regulation of systemic arterial blood pressure by atrial natriuretic peptide

2

1

2.30E−03

1

GO:1902412

BP

Regulation of mitotic cytokinesis

6

1

2.31E−03

1

GO:0021691

BP

Cerebellar Purkinje cell layer maturation

2

1

2.45E−03

1

GO:0021590

BP

Cerebellum maturation

3

1

2.56E−03

1

GO:0021699

BP

Cerebellar cortex maturation

3

1

2.56E−03

1

GO:0046340

BP

Diacylglycerol catabolic process

4

1

4.06E−03

1

GO:0051315

BP

Attachment of mitotic spindle microtubules to kinetochore

13

1

4.23E−03

1

GO:0021578

BP

Hindbrain maturation

6

1

4.40E−03

1

GO:0021626

BP

Central nervous system maturation

7

1

4.51E−03

1