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Fig. 4 | Genome Medicine

Fig. 4

From: T cell receptor beta germline variability is revealed by inference from repertoire data

Fig. 4

TRBD and TRBJ usage correspond to TRBD2 genotype. A TRBD and TRBJ gene usage in DS4 individuals with different TRBD2 genotypes. TRBJ genes are shown along the X-axis in the order in which they appear in the genome. B The TRBJ family usage in DS4 individuals with different TRBD2 genotypes. TRBJ families are shown along the X-axis in the order in which they appear in the genome. C TRBJ gene usage normalized to the TRBJ family usage, in DS4 individuals with different TRBD2 genotypes. TRBJ genes are shown along the X-axis in the order in which they appear in the genome. D The relative fraction of TRBJ2 genes out of the sequences that were assigned to TRBD2 and were longer than 7nt. E The fraction of TRBJ2 genes out of the sequences that were assigned to TRBD1 and were longer than 7nt. TRBJ genes are shown along the X-axis in the order in which they appear in the genome. F The fraction of TRBJ genes out of the sequences that were assigned to TRBD1 and were longer than 7nt. TRBJ genes are shown along the X-axis in the order in which they appear in the genome. The box colors correspond to the TRBD2 genotype. Statistical significance was determined using a Mann–Whitney test and adjusted by Bonferroni correction (n.s.not significant, *p < 0.05, **p < 0.01, and ***p < 0.001)

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