Fig. 1
From: T cell receptor beta germline variability is revealed by inference from repertoire data
Overview of TRB genotyping and haplotyping workflow, TCR β sequencing technologies, and number of documented alleles. A An illustration of the steps for TRB genotyping and haplotyping. The input is an AIRR-seq fasta file after preprocessing, according to the sequencing protocol described in the “Methods” section (see the “Data” section). B An illustration of the three TCR β sequencing approaches investigated in this study. C Heatmaps of distances between amplified TRBV gene sequences. The three panels correspond to the sequencing approaches shown above them. Colors correspond to the distances between the genes as measured by the minimum global alignment score (with a padded beginning and a penalty of one for each mismatch, insertion, or deletion) between the closest two alleles in the sequenced region. D Barplot of the unique sequence number per gene in the studied sequencing approaches