Skip to main content
Fig. 2 | Genome Medicine

Fig. 2

From: Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer

Fig. 2

The four molecular subtypes are represented in PDX models. A Genomic characteristics of endometrial carcinoma and carcinosarcoma PDX models. PDX models are grouped by the four molecular subtypes: POLE, CN-low, MMRd, and CN-high/p53mut. Tumor mutation burden is shown by gray bars, as mutations per Mb using a log10 scale. Somatic mutations and CNA events, which were detected in PDX samples in MMR genes and genes relevant to endometrial carcinomas and carcinosarcomas (Additional File 1: Table S3, Additional File 2: Table S4), are shown. Only consensus variants detected in all sequenced PDX tumor samples were included in this figure. MSI score was assessed by MSISensor (Additional File 1: Fig. S3). Percentage of genome with CNA and the number of CNA segments were determined from SNP arrays or WGS data (Additional File 1: Fig. S4). Only the dominant mutational signature etiology is shown. B Representative B-allele frequency plots of CN-low and CN-high PDX models

Back to article page