Table 1 Main characteristics of NBD subtypes
From: Emerging genetic complexity and rare genetic variants in neurodegenerative brain diseases
NBD | Brain location | Pathology | Main symptoms |
|---|---|---|---|
AD | Tempo-parietal lobes | β-Amyloid, tau | Progressive memory loss, cognitive decline |
FTD | Frontotemporal lobe | TDP43, tau, FUS | Behavioral changes, language deficits |
PD | Midbrain | α-Synuclein, Lewy bodies | Bradykinesia, muscle rigidity, resting tremor. Dementia features in 30–80% |
ALS | Motor cortex, spinal cord | TDP-43 | Muscle weakness, impaired voluntary movements. Dementia features in 50% |