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Table 1 Main findings from trans-ethnic EWAS meta-analyses for 13 replicated DMPs

From: Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

    

Our study discovery

Sample size by DNAm array

Replication GS/CATHGEN/HyperGEN

Combined discovery and replication

DMP

Chr

Position (hg38)

Gene

Effect

p

450K

EPIC 850 K

Effect

p

Effect

p

cg13235761^

1

203,592,452

 

− 37.61

4.33E−06

3048

2378

− 25.28

5.08E−05

− 29.81

1.88E−09

cg26099045^*

2

64,064,666

 

14.82

5.74E−06

3050

2378

11.24

1.01E−04

12.81

3.26E−09

cg04428662^Ω*

4

2,932,461

MFSD10

− 30.84

3.21E−06

3049

2378

− 34.94

3.43E−07

− 32.82

5.51E−12

cg23174201^*

5

151,674,695

SPARC

− 35.83

5.10E−06

3050

2378

− 34.87

1.72E−07

− 35.27

4.02E−12

cg17170437

6

44,229,461

SLC29A1

− 47.62

1.96E−06

N/A

2378

− 18.62

1.49E−04

− 24.24

3.80E−08

cg14871770

10

96,658,622

CYP2C9, CYPC19

− 53.12

1.98E−06

N/A

2378

− 25.87

1.70E−04

− 33.36

1.23E−08

cg02157636

11

68,709,367

TESMIN

− 53.21

2.15E−06

N/A

2378

− 27.25

1.14E−05

− 33.33

8.58E−10

cg26039141^Ω

11

75,402,116

RPS3

− 39.14

3.40E−06

3050

2378

− 33.42

1.78E−05

− 36.06

2.90E−10

cg22593432^*

13

32,001,768

 

− 29.91

1.54E−07

3050

2378

− 17.66

1.79E−04

− 22.64

4.61E−10

cg11789371^*

14

102,085,048

HSP90AA1

− 35.40

4.44E−06

3050

2378

− 22.66

3.58E−04

− 27.80

1.41E−08

cg05796561

18

57,128,273

 

− 45.24

2.96E−06

N/A

2378

− 22.91

1.69E−04

− 29.24

1.41E−08

cg17944885^Ω*

19

12,114,920

ZNF20, ZNF788P

− 32.71

1.41E−09

3048

2378

− 16.34

5.67E−07

− 20.72

1.24E−13

cg15787712^

19

13,837,429

LOC284454, MIR23

− 37.60

6.00E−09

3050

2378

− 28.65

2.06E−05

− 33.30

9.01E−13

  1. p-value for replication < 6.4E−04 (Bonferroni correction for 78 DMPs tested). Four of the 13 DMPs that replicated were non-450K probes (cg17170437, cg14871770, cg02157636, cg05796561). Results from combined discovery and replication are also shown
  2. GS Generation Scotland, N/A not applicable
  3. ^cis-meQTL from the BIOS QTL [36, 37]
  4. ΩExpression quantitative trait methylation (eQTM) data from the BIOS QTL (enrichment p-value <0.01) [36, 37]
  5. *cis-meQTL in the Framingham Heart Study [38]