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Fig. 3 | Genome Medicine

Fig. 3

From: Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma

Fig. 3

The associations between host liver gene expression and gut microbes in patients with HCC. a Differential expression of the microbe-associated genes from 32 paired tumor and adjacent non-tumor liver tissue samples. b Pearson correlation coefficients of 31 OTU-gene pairs, and P values evaluated by Student’s t test for comparing the difference in log2FC values calculated by GFOLD between small HCC and non-small HCC subgroups. Scatter diagrams and Cox hazards models of two typical OTU-gene pairs, OTU_0134-CD6 (c) and OTU_0002-MAPK10 (d). The x-axis of the scatter diagram indicates the OTU abundance. The y-axis indicates log2FC of gene expression calculated by GFOLD. Each point represents a patient (red: non-small HCC; blue: small HCC), and some points coincided at the origin. Immunohistochemical staining showed that CD6 (e) and MAPK10 (f) were highly expressed in tumor tissues of patients with small HCC versus non-small HCC (× 200)

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Genome Medicine

ISSN: 1756-994X

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