Table 1 List of 44 APOBEC-associated hotspot mutations and their frequencies in bladder cancer (n = 602)

FGFR3 S249C

51

PIK3CA E545K

47

ERBB2 S310F

27

PIK3CA E542K

25

RXRA S427F

19

TP53 E285K

17

TP53 R280T

15

KDM6A Q555*

11

TBC1D12 *1*

11

C3orf70 S6L

10

RHOB E172K

9

AHR Q383H

8

LPAR6 F316F

8

TP53 Q331*

8

TP53 E271K

8

RARS2 R6C

7

SF3B1 E902K

7

TP53 R280K

7

ERBB3 E332K

6

MROH2B E1109K

6

PIK3CA E545Q

6

PPCS S113L

6

STAG2 Q593*

6

ACSS3 S290L

5

CELSR3 E356K

5

KCNF1 E158K

5

PDE3A L275L

5

PIK3CA E726K

5

PLXNA2 E1480K

5

RHOB E47K

5

TFPI2 R222C

5

TP53 K132N

5

CAMK2G I132I

4

CELSR1 E1382K

4

EP300 Q1082*

4

ERBB4 E317K

4

FAM90A1 L251L

4

FURIN R693W

4

KDM6A S1061*

4

PBX2 E70K

4

RB1 Q217*

4

RREB1 Q392*

4

TP53 Q192*

4

TTC23L Q263Q

4