Fig. 5

Prediction for new ‘driver’ and ‘passenger’ hotspots using combined analysis of DNA loop stability and mRNA expression levels of APOBEC-target genes in bladder cancer (BCa). Higher normalised ΔG (kcal/mol) scores reflect lower loop stability. Gene expression level (normalised against GAPDH gene) is presented by rank at the whole-transcriptome scale in tumours samples. Passengers include 5 silent mutations, 1 mutation within a transit peptide and 1 missense mutation on a gene with an absence of mRNA expression. The functional attributions for mutations and genes are curated from a recent publication [41]. OG, oncogene; TSG, tumour suppressor gene