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Fig. 3 | Genome Medicine

Fig. 3

From: Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

Fig. 3

A space filled model of the wild type SARS-CoV-2 S glycoprotein in a trimeric form using the sequence of a the native or b spike deletant virus, in which the aa’s 679NSPRRARSV687 have been replaced with isoleucine. The model was built using a cryo-EM structure (6VSB.pdb) of the S glycoprotein in the prefusion form (25). Each of the monomers is coloured differently. The loop containing the furin cleavage site (or the shortened loop in the deleted version in b) is indicated in red. The positions of phosphorylation sites identified by mass spectrometry and surface located were mapped on the native structure and shown in yellow in a

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