Fig. 4
From: Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time
ITH simulation, inferring the optimal number of subclones and entropy. The left plot pertains to Spearman correlations between the true and inferred number of subclones across simulated replicates as a function of sequencing depth and ITH method. The number of subclones are estimated by PyClone (PyClone), PhyloWGS (PhyloWGS), and SMASH using optimal BIC (SMASH(oS)). The right plot pertains to Spearman correlations between the true and estimated entropy using the optimal tree from PhyloWGS (PhyloWGS), optimally inferred entropy from SMASH (SMASH(oE)), and weighted entropy from SMASH (SMASH(wE))