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Fig. 7 | Genome Medicine

Fig. 7

From: Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility

Fig. 7

The effect of MS risk SNP genotype on the expression of TRAF3. a Risk SNP rs12588969 is a binding site for the EBV transcription factor EBNA2. The inhibitory effect of CD40L on LCL proliferation is greater for the protective genotype (GG) of rs1214050 (b). Difference in proliferation (Y axis) is the difference in proliferation of LCLs over 5 days cultured with or without CD40L, measured by median fluorescence intensity of cell trace violet. TRAF3 expression is genotype dependent in CD19+B cells for MS risk SNPs rs12147246 (measured by proxy SNP rs1214050) (c) and rs12588969 (d). * < 0.05, ***, < 0.001

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