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Fig. 6 | Genome Medicine

Fig. 6

From: Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility

Fig. 6

MS risk gene CD40 expression and signalling in B cells and LCLs. a Risk SNP rs1883832 is a binding site for the EBV transcription factor EBNA2. b The proportion of full length CD40 mRNA is higher in LCLs compared to CD19+ B cells, independent of rs1883832 genotype. c CD40L inhibits LCL proliferation (d) The inhibitory effect of CD40L on LCL proliferation is greater for the protective genotype (CC). Difference in proliferation (Y axis) is the difference in proliferation of LCLs over 5 days cultured with or without CD40L, measured by median fluorescence intensity of cell trace violet. * < 0.05,*** < 0.001, **** < 0.0001

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Genome Medicine

ISSN: 1756-994X

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