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Fig. 3 | Genome Medicine

Fig. 3

From: Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility

Fig. 3

Genes and pathways with a stronger association of expression in LCLs compared to whole blood. a Heat map showing expression level of genes corresponding to the SNP:gene pairs that were more strongly associated with expression in LCLs compared to whole blood (LCLeQTL*) in CD19+ B cells and LCLs. b Over-representation of pathways and networks in LCLeQTL*(MSRG eQTLs in LCL (p < 0.05) with stronger/opposite effect than in whole blood); LCLeQTL(MSRG eQTLs in LCL (p < 0.05)); WB eQTL minus LCLeQTL*(MSRG eQTL in whole blood (p < 0.05) minus MSRG eQTLs in LCL (p < 0.05) with stronger/opposite effect than in whole blood); genes dysregulated in LCLs vs CD19+ B cells at 1% FDR; MSRG with EBV transcription factor binding sites; MSRG, genes proximal to MS risk SNPs. TF, transcription factor. P values were calculated using MetaCore (Clarivate Analytics)

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