Fig. 3

Functional analysis of the expression modules. a Enriched gene sets from GO, KEGG and Reactome databases (yellow background; p < 0.05, Fisher’s exact test) and of B cell-related signatures taken from [47,48,49] and from a separate analysis of our B cell samples (blue background) are assigned to each of the spot modules. For example, spots A and F associate with cell-cycle activity and inflammation, respectively. b Mapping of key genes mutated in lymphomas and multiple myeloma taken from [50,51,52,53,54,55,56,57,58,59,60] into the expression landscape: Most of the genes accumulate in or near the spot modules thus reflecting a subtype-specific modulation of their gene expression. Multiple appearances of gene names refer to different Affymetrix probe sets