From: Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma
Var | Somatic variant (single nucleotide variant [SNV], insertion/deletion [InDel], frameshift variant) |
Varns | Non-synonymous somatic variant (i.e., somatic mutation) |
Varexp | Expressed non-synonymous somatic variant |
PNE | Predicted mutated neoepitope |
PNEexp | Predicted mutated neoepitope with evidence on transcript level |
PNEprot | Predicted mutated neoepitope with evidence on proteome level |
NElig | Mutated neoantigen with evidence on HLA ligandome level (HLA class I) |
WTlig | Wild-type peptide corresponding to PNE with evidence on HLA ligandome level (HLA class I) |
neoantigen/neoepitope | Mutated HLA-presented peptide (potentially) recognizable by (T cells of) the immune system |
TMB | Tumor mutational burden (non-synonymous somatic variants per megabase) |