Fig. 5From: CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modelingCRISPR/Cas9 enables generation of bioluminescent liver tumors. a Schematic showing the target genomic locus, guide RNAs, and donor plasmid. Hydrodynamic tail vein injection was performed to deliver the CRISPR/Cas9 system to FVB mice. b, c IVIS imaging was performed weekly. d H&E and Ck19 IHC staining of liver tumors. Dashed lines denote tumor/liver border. Scale bars are 25 μmBack to article page