From: Single-cell analysis reveals congruence between kidney organoids and human fetal kidney
Cluster and sample origin | DE | Top enriched genes | GO summary for ≥ 10 DE genes | Top cluster markers | Top conserved markers | |
---|---|---|---|---|---|---|
CN0 Pod | hFK | 79 | TUB1A1, NR2F1, SOX4, LGALS1, NUSAP1, LYPD1 | Central nervous system development | S100A6, TCF21, PODXL, TPPP3, SBSPON, MMP5, CPXM1, DUSP23, THSD7A, MME | TCF21, MME, PODXL, THSD7A, TPPP3, SBSPON, MAFB, ENPEP, ROBO2, NPHS2 |
Org | 175 | VAMP8, ANXA1, AIF1, S100A4, TGFBR3, WT1 | ATP synthesis, oxidative phosphorylation | |||
CN1 Diff. NP | hFK | 37 | CCND1, PCNA, CXCR4, TUBA1A, TBUA1B, STMN1 | mRNA splicing | LYPD1, PAX8, HIST1H4C, PCLAF, CDH6, DAPL1, CCND1, RBP1, HMGB2 | LYPD1, PAX8, HIST1H4C, PCLAF, DAPL1, PCP4, HEY1, CDH6, RBP1, PAX2 |
Org | 4 | FTL, GNAS, BNIP, ATOX1 | Â | |||
CN2 NP | hFK | 24 | TMEM100, ITM2C, MEOX1, EPCAM, ROBO2, DAPL1 | Amyloid precursor biosynthesis | ACTC1, NNAT, MYLPF, MYL1, TMEM100, TPM2, CRABP2, TUB1A1 | NNAT, CRABP2, TUB1A1, IGF2, SIX1, TMEM100, CITED1, SOX4, MEOX1, MEIS2 |
Org | 25 | ACT1C1, MYLPF, TPM2, PITX2, MYOG, MYOD | Muscle filament sliding | |||
CN3 Pod. Pre. | hFK | 37 | CCND1, OLFM3, CXCL1, HNRNPR, STMN1 | No significant BP terms | CTGF, GPX3, TSPAN8, PAPPA, PAPPA, ITIH5, SERINC5, HES4, NPHS2, NPHS1, MAFB, PTPRO | CTGF, OLFM3, BCAM, NPHS1, ARHGAP29, CLDN1, LEPROT, TMP1, STON2, CLDN5, MAFB |
Org | 78 | GPX3, ANXA1, S100A4, AIF1, PTPRO, SYNPO, VEGFA, WT1 | Epithelial cell diff. involved in kidney development | |||
CN4 Distal | hFK | 26 | PTGR1, MAL, LIMCH1, ELF3, ALDH1A1, PAPPA2 | Epithelium development | HBG2, ATF3, LIMCH1, MAL, WFDC2, BTG2, HES1, KLF6, MECOM, ELF3, TUBB2B, GATA3 | WFDC2, EMX2, LIMCH1, MAL, TUBB2B, SAT1, MECOM, HMGA1, HES1, GATA3, ATP1B1, GNG11 |
Org | 11 | LHX1, BNIP3, FTL, CKB, BASP1, CITED2, HNRNPAB | Kidney morphogenesis | |||
CN5 Proximal | hFK | 34 | CCND1, CA2, VCAN, ELF3, DCDC2, FLRT3 | No significant BP terms | IGFBP7, CD24, PCP4, PCSK1N, FXYD2, EMX2, MPC2, APOE, CLU, CFAP126, FTL, ATP1B1 | IGFBP7, MPC2, SMIM24, FLRT3, EMX2, FXYD2, GNG11, TSPAN12, CLU, PCP4, ATP1B1, PDZK1 |
Org | 14 | PCSK1N, CITED2, BNIP3, S100A13, MLLT1, PRDX5, VAMP8, LHX1 | Ureteric bud morphogenesis, pronephros development | |||
CN7 hFK Pod | hFK | Â | Â | Â | CXCL12, TNNI1, TNNT2, MME, MYL9, MRGPRF, TPPP3, ANXA2, COL4A4, ADM, PTPRO, MSMO1 | N/A |
Org | Â | Â | Â |