Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

Table 1 Results of the expression quantitative trait loci-wide association study (eQTLWAS) between genetic variants influencing gene expression and cardiovascular traits in ALSPAC

Tag SNP	Gene(s)	Trait	Sample size	Beta	SE	P value
rs646776	SORT1; CELSR2; PSRC1	Total cholesterol	4543	− 0.099	0.016	1.10 × 10⁻⁹
rs646776	SORT1; CELSR2; PSRC1	LDL cholesterol	4543	− 0.110	0.015	7.74 × 10⁻¹⁴
rs646776	SORT1; CELSR2; PSRC1	ApoB	4546	− 2.695	0.328	2.66 × 10⁻¹⁶
rs12129500	IL6R	IL-6	4503	− 0.126	0.018	4.96 × 10⁻¹²
rs11693654	ADCY3; NCOA1; CENPO	BMI	6387	0.200	0.036	3.57 × 10⁻⁸
rs80026582	LPL	Triglycerides	4334	− 0.101	0.018	1.49 × 10⁻⁸
rs80026582	LPL	VLDL cholesterol	4334	− 0.100	0.018	1.57 × 10⁻⁸
rs600038	ABO	IL-6	4496	− 0.207	0.021	4.12 × 10²²
rs174538	FADS1; FADS2; TMEM258	Total cholesterol	4539	− 0.080	0.015	5.03 × 10⁻⁸
rs2727784	APOA1; TAGLN	ApoA1	4018	3.047	0.468	8.05 × 10⁻¹¹
rs10419998	GATAD2A; MAU2; TM6SF2	ApoB	4404	− 2.024	0.376	7.96 × 10⁻⁸

Abbreviations for the column headings from left to right: single nucleotide polymorphism, gene or gene cluster associated with SNP, associated trait, sample size for this effect, observed effect size, standard error of the effect size, P value for the observed effect

ISSN: 1756-994X