Table 2 Comparison between the results of cell line sensitivity of cell lines with actionable mutations and TCGA protein profile discriminability. For each actionable gene-histotype combination, Y = yes and N = no indicate whether cell lines with actionable mutations show different drug response than cell lines without actionable mutation and if protein profiles of actionable TCGA cases of the specific histotypes have been discriminable from non-actionable ones

BRAF

SKCM*

Y

Y

ERBB2

BRCA*

Y

Y

STAD*

Y

Y

LUAD

Y

Y

PAAD

N

N

EGFR

LUAD*

Y

Y

FGFR1

LUSC*

Y

Y

COAD

N

N

UCEC

N

Y

SKCM*

Y

Y

KRAS

LUAD

Y

Y

UCEC

N

Y

COAD*

N

N

STAD

N

N

LUAD

Y

Y

MET

GBM

N

Y

SKCM

N

N

STAD

Y

N

BRCA

N

Y

KIRP

Y

Y

KIRC*

N

N

OV

N

Y

LUAD

Y

Y

PIK3CA

BLCA

Y

N

HNSC

N

N

STAD

N

Y