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Fig. 2 | Genome Medicine

Fig. 2

From: Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

Fig. 2

Mutational and proteomic cross-cancer similarities. Chord diagrams show the cross-cancer similarities for somatic mutations (left) and protein profiles (right) by computing for each case the closest molecular neighbor among all 3590 tumors for which mutational and proteomic data were available. Chords connecting two histological tumor types indicate the number of tumors of a certain cancer that are—on the level of mutations or protein profiles—more similar to tumors of the other type than to their own, indicating a disagreement of molecular and histological type. Hill-like structures, on the other hand, indicate the amount of cases where molecular and histological classes are identical. It is obvious that a substantial disagreement exists only for mutational profiles (similar results for copy number variation,  Additional file 1: Figure S4) showing agreement between mutational and histological tumor types in only 45% of the cases, whereas protein profiles are consistent with histological tumor types in over 94%

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