Fig. 2
Plasmid variants associated with different iro and/or iuc lineages identified amongst K. pneumoniae. a Clustering of the 12 reference plasmids based on gene content, annotated with the presence of iuc and iro lineages (coloured as in panel b and Fig. 1c), rmpA, IncFIBK, IncFIB, IncFII and/or other plasmid replicon types. b Gene content matrix for reference plasmids; columns correspond to protein-coding sequences that are > 10% divergent from one another. IncFII tra-trb conjugal transfer region genes are coloured blue, to highlight the divergent forms of this region and labelled with the closest IncFII type as detected by PlasmidFinder. c Genetic maps for the reference plasmids. The positions of key loci involved in core plasmid functions (bold), virulence (iro highlighted in yellow, iuc in dark orange and other loci involved in iron acquisition/transport in light orange) and antimicrobial resistance are indicated. Grey shading indicates homology blocks sharing > 60% nucleotide identity