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Fig. 2 | Genome Medicine

Fig. 2

From: T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

Fig. 2

Analysis of TCRB CDR3 sequences. a The unique numbers of rearranged genes detected are shown. The colors indicate in frame rearrangements (blue), frameshifts (tan), and stop codons (red). b Richness and evenness of the inferred TCRB CDR3 populations. Patients are color coded as indicated on the right, and all replicates for each patient timepoint displayed. The ranges of healthy adults and children are shown by the light and dark gray diamonds, respectively. c Clustering of the samples sequenced using Bray-Curtis similarity and t-SNE. The association of patients with samples is shown by the key at the right. d V gene usage. The patient of origin is marked at the top of each panel. The V genes shown were the top most commonly found V genes in healthy children, ordered by prevalence; not all V genes used by each patient are shown. All panels show the same x-axis of V genes. Chi-squared test used to assess differences between gene distribution in patients compared to healthy children; red label indicates significant difference from healthy (p < 0.05). e J gene usage, with J genes determined by the same manner as in D. f Heat map summarizing the frequencies of utilization of the most common V and J pairs. Subjects studied are marked at the top. Time of sampling is shown on the right

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