Table 2 Maternal and fetal genome-wide significant association of maternal and neonatal cytokines/chemokines
From: Cross-genetic determination of maternal and neonatal immune mediators during pregnancy
SNP | gen | chr | A1 | MAF | Beta | SE | P value | Locus | SIM | Set | PÂ value match-gen |
|---|---|---|---|---|---|---|---|---|---|---|---|
rs12327057 | Fetal | 18p11 | C | 0.18 | − 0.42 | 0.07 | 1.4 × 10−8 | ADCYAP1 | sIL2R-α | M | 9.4 × 10−4 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.53 | 0.05 | 8.6 × 10−21 | PLCL2 | CCL17 | I | 3.8 × 10−6 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.48 | 0.05 | 3.3 × 10−20 | PLCL2 | CCL19 | I | 3.8 × 10−6 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.36 | 0.04 | 2.8 × 10−19 | PLCL2 | CXCL9 | I | 5.4 × 10−6 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.23 | 0.03 | 8.2 × 10−13 | PLCL2 | CCL7 | I | 1.1 × 10−3 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.24 | 0.03 | 5.2 × 10−12 | PLCL2 | IFN-γ | I | 6.0 × 10−3 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.27 | 0.04 | 2.1 × 10−12 | PLCL2 | IL-2 | I | 1.5 × 10−3 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.26 | 0.04 | 1.7 × 10−11 | PLCL2 | IL-6 | I | 9.7 × 10−4 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.20 | 0.03 | 1.8 × 10−11 | PLCL2 | IL-10 | I | 3.8 × 10−4 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.22 | 0.03 | 3.5 × 10−10 | PLCL2 | IL-1β | I | 1.4 × 10−3 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.17 | 0.03 | 9.3 × 10−10 | PLCL2 | CXCL13 | I | 1.3 × 10−4 |
rs75885714 | Fetal | 3p24.3 | C | 0.08 | − 0.16 | 0.03 | 2.0 × 10−8 | PLCL2 | CX3CL1 | I | 9.8 × 10−4 |
rs1003645 | Fetal | 17q12 | C | 0.28 | − 0.63 | 0.02 | 2.5 × 10−100 | CCL23 | CCL23 | I | 3.4 × 10−24 |
rs854625 | Fetal | 17q12 | A | 0.12 | 0.47 | 0.04 | 4.6 × 10−25 | CCL15 | CCL15 | I | 1.1 × 10−6 |
rs3921 | Fetal | 4q21.1 | C | 0.29 | 0.24 | 0.03 | 2.0 × 10−14 | CXCL9/10/11 | CXCL11 | I | 1.2 × 10−3 |
rs16850073 | Fetal | 4q13.3 | T | 0.32 | 0.10 | 0.02 | 6.4 × 10−9 | CXCL6 | CXCL6 | I | 6.8 × 10−6 |
rs73359750 | Fetal | 7q11.23 | T | 0.08 | 0.86 | 0.16 | 4.9 × 10−8 | CCL24 | CCL24 | I | NS |
rs41272321 | Fetal | 3q22.1 | G | 0.13 | − 0.20 | 0.03 | 2.8 × 10−10 | ACKR4 | CCL21 | I | 3.3 × 10−4 |
rs2228467 | Fetal | 3p22.1 | C | 0.04 | 0.29 | 0.05 | 2.8 × 10−8 | ACKR2 | CXCL9 | I | 0.01 |
rs2228467 | Fetal | 3p22.1 | C | 0.04 | 0.42 | 0.07 | 4.4 × 10−9 | ACKR2 | CCL19 | I | 0.03 |
rs2228467 | Fetal | 3p22.1 | C | 0.04 | 0.48 | 0.07 | 1.8 × 10−10 | ACKR2 | CCL17 | I | 0.02 |
rs74331971 | Fetal | 8p23.3 | A | 0.03 | − 0.40 | 0.07 | 1.9 × 10−9 | FBXO25/TDRP | IL-4 | I | 0.03 |
rs4303899 | Fetal | 3q13.32 | G | 0.12 | − 0.09 | 0.02 | 1.7 × 10−8 | lincRNA | CXCL12 | I | NS |
rs115463265 | Maternal | 3p24.2 | T | 0.02 | − 1.50 | 0.24 | 1.6 × 10−9 | THRB/RARB | CCL11 | M | NS |
rs12778662 | Maternal | 10p15.1 | T | 0.07 | 0.65 | 0.11 | 3.7 × 10−9 | IL2R | sIL2R-α | M | 0.04 |
rs1562064 | Maternal | 4q31.21 | G | 0.32 | − 0.74 | 0.13 | 2.1 × 10−8 | near SMAD1 | IL1-α | M | 1.5 × 10−3 |
rs34642455 | Maternal | 7q22.1 | C | 0.13 | − 2.17 | 0.38 | 3.1 × 10−8 | CYP3A4 | CXCL5 | I | 3.6 × 10−3 |
rs72751339 | Maternal | 15q26.2 | T | 0.02 | − 1.52 | 0.25 | 1.3 × 10−8 | MCTP2 | CCL24 | I | 1.7 × 10−3 |
rs17159338 | Maternal | 5q21.3 | C | 0.03 | − 0.36 | 0.06 | 1.2 × 10−9 | near EFNA5 | IL-16 | I | NS |