Fig. 5
From: Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins
Prevailing and suggested models of RA disease development. The current model of RA aetiology primarily involves the contribution of genetic and non-genetic factors including triggers such as infection, which mediate an immune response and ultimately contribute to the clinical manifestation of RA. Our suggested model of RA development incorporates the potential role of DNA methylation alongside the contributing factors of oxidative and cellular stress