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Fig. 3 | Genome Medicine

Fig. 3

From: Single-cell transcriptome analysis of lineage diversity in high-grade glioma

Fig. 3

a t-SNE projections of the transformed population of cells from each of the eight HGGs from scRNA-Seq. The projections are colored based on the cellular subpopulations identified from unsupervised clustering. b Heatmaps showing the detection frequency of canonical astrocyte, OPC, oligodendrocyte, and neuroblast markers found to be specifically associated with transformed cellular subpopulations shown in a across multiple patients along with SOX2, which is expressed across all transformed populations. The orange heatmap below each green heatmap shows the average detection frequency of cell cycle control genes found in each subpopulation. Note that some tumors have subpopulations resembling multiple neural lineages (PJ016, PJ018, PJ030, PJ048), while others exhibit a relative loss of neural lineage identity and concomitant reduction in proliferation

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