Table 1 Homozygous single nucleotide polymorphisms (SNPs) in P. falciparum drug resistance gene orthologs detected in the 69 Plasmodium vivax sequences
Locus | Chr | Position | Ref | Alt | Amino acid | Samples* |
|---|---|---|---|---|---|---|
pvcrt-0 (PVX_087980) | 1 | 331,151 | T | C | Intron | 61 (67) |
331,819 | G | A | Intron | 29 (69) | ||
332,453 | T | C | Intron | 59 (68) | ||
332,874 | A | C | Intron | 67 (68) | ||
pvdhfr (PVX_089950) | 5 | 964,760 | C | G | Phe57Leu | 2 (66) |
964,762 | G | A | Ser58Asn | 4 (63) | ||
964,763 | C | G,A | Ser58Arg | 55 (59) | ||
964,939 | G | A | Ser117Asn | 58 (62) | ||
pvmdr1 (PVX_080100) | 10 | 362,888 | A | G | Phe1070Leu | 6 (49) |
363,223 | A | G | Thr958Met | 44 (46) | ||
363,374 | T | G | Met908Leu | 46 (47) | ||
365,435 | C | A | Val221Leu | 9 (49) | ||
Multidrug resistance protein 2 (PVX_118100) | 12 | 2,413,549 | A | T | Tyr514Phe | 6 (58) |
2,415,530 | G | T | Gln1174His | 23 (57) | ||
2,415,666 | G | A | Gly1220Ser | 11 (60) | ||
2,416,390 | C | T | Ala1461Val | 1 (63) | ||
2,416,408 | T | C | Val1467Ala | 31 (41) | ||
2,416,420 | T | C | Leu1471Pro | 12 (62) | ||
2,416,438 | T | C | Leu1477Pro | 2 (63) | ||
Multidrug resistance-associated protein 2 (PVX_124085) | 14 | 2,043,859 | G | C | Gln1407Glu | 11 (13) |
2,045,050 | C | T | Val1010Met | 14 (15) | ||
2,047,090 | G | A | Pro330Ser | 1 (15) | ||
2,047,233 | C | A | Arg282Met | 13 (14) | ||
2,047,816 | C | G | Glu88Gln | 3 (18) | ||
dhps (PVX_123230) | 14 | 1,257,856 | G | C | Ala383Gly | 9 (15) |
1,258,389 | C | T | Met205Ile | 10 (12) |