Fig. 3

Differentially methylated regions in PDXs derived from NCSLC. a Barplot representing the fold enrichment of global distribution of differential hyper- and hypomethylation in PDX overlapping with regions of interest (ROIs). b Fold enrichment of the seven most significantly differentially methylated ENCODE-defined TFBS in PDXs for hypermethylation and in c for hypomethylation, respectively. The bars represent the odds ratio of the fraction of DMRs within all windows that are overlapping respective regions of interest (e.g., promoters, TFBS) over the fraction of DMRs in the whole genome. TFBS transcription factor binding site, CGI CpG island