Disease-specific regulation of gene expression in a comparative analysis of juvenile idiopathic arthritis and inflammatory bowel disease

Table 1 GWAS eQTL

Gene	rsID	IBD β	IBD p val	JIA β	JIA p val	IBD-GWAS	ATH-GWAS	Interact p
ARPC2	rs13429408	0.82	6.60E−05	0.18	0.22	CD, UC	–	0.01
CPTP	rs11809901	− 1.08	9.80E−05	− 0.12	0.69	CD, UC	–	0.04
PAM	rs2431321	1.04	3.80E−09	1.15	2.10E−23	–	RA	0.48
PAM	rs32677	0.21	0.3	0.94	5.30E−15	–	RA	9.60E−05
C5	rs1468673	0.39	0.02	0.74	3.10E−07	–	RA	0.34
PRDX6	rs4279882	1.84	3.80E−05	0.36	0.05	–	RA	0.001
ADAM1A	rs11066027	1.22	2.40E−05	0.61	5.30E−03	–	JIA, RA	0.09
RNASET2	rs385863	− 0.68	1.30E−04	− 1.05	1.40E−14	CD, UC	RA	0.3
GSDMB	rs11078926	− 0.51	5.90E−03	− 0.56	9.90E−07	CD, UC	RA	0.87
SLC22A5	rs11739135	0.09	0.6	− 0.8	9.80E−10	CD, UC	JIA	4.00E−05
SLC22A5	rs11950562	− 0.53	8.00E−04	− 0.86	6.10E−14	CD, UC	JIA	0.07
ORMDL3	rs1565923	1.11	8.80E−07	0.47	6.20E−04	CD, UC	RA	0.01
ICAM4	rs3093029	1.22	4.80E−04	1.3	2.90E−08	CD, UC	JIA	0.69
RMI2	rs11644184	− 0.58	7.60E−04	− 0.7	3.00E−07	CD, UC	JIA	0.54
PLTP	rs7275164	− 0.56	2.10E−04	− 0.71	7.00E−07	CD, UC	RA	0.58
CD226	rs12969613	0.63	2.20E−07	0.18	0.15	CD, UC	RA	0.11
NOD2	rs1981760	1.28	2.70E−08	1.05	2.30E−16	CD	–	0.23
GBAP1	rs914615	0.6	3.20E−04	0.8	7.80E−10	CD	–	0.62
GBAP1	rs3814319	0.16	0.33	0.7	1.20E−06	CD	–	0.05
KSR1	rs2945378	− 0.48	6.20E−03	− 0.6	4.40E−07	CD	–	0.52
SULT1A1	rs7191548	− 0.49	6.50E−03	− 0.61	5.30E−07	CD, UC	–	0.93
PNKD	rs13430006	0.34	0.14	0.57	6.80E−07	CD, UC	–	0.41
NLRP2	rs12975582	0.56	0.01	0.8	1.20E−06	CD, UC	–	0.43
SLC11A1	rs78846874	− 0.35	0.36	− 0.83	3.90E−06	CD, UC	–	0.22
LGALS9	rs1984547	− 0.88	2.40E−05	− 0.55	4.10E−05	CD, UC	–	0.16

ISSN: 1756-994X