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Fig. 4 | Genome Medicine

Fig. 4

From: Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Fig. 4

Effect of the APOE ε4 allele and TREM2 coding variants on the cellular population structure. Mean neuronal (blue) and astrocytic (red) proportions for (a) AD cases and controls in the Knight-ADRC brains categorized by APOE ε4 carriers vs non-carriers and (b) AD cases of Knight-ADRC brain bank (bars indicate standard deviations). c AD cases and controls in the Mayo Clinic and MSBB. d AD cases in the Mayo Clinic and MSBB. e Neuronal (blue) and astrocyte (red) distributions for samples included in the MSBB stratified by TREM2 genetic status. APC anterior prefrontal cortex, STG superior temporal gyrus, PHG parahippocampal gyrus, IFG inferior frontal gyrus (n.s. p > 0.05; *p < 0.05; ****p < 1.0 × 10−4)

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