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Fig. 3 | Genome Medicine

Fig. 3

From: Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Fig. 3

Neuron and astrocyte distributions from the DIAN and Knight-ADRC brains. a Mean neuronal (blue) and astrocytic (red) proportions for carriers of pathogenic mutations in APP, PSEN1, or PSEN2 (ADAD), late-onset AD (LOAD), and neuropath-free controls (bars indicate standard deviations). Neuronal and astrocytic proportions plotted against (b) Braak staging and (c) by CDR. d Cell-type distributions for carriers of AD genetic risk factors. Lines indicate significance levels (*p < 0.05; **p < 0.01; ***p < 1.0 × 10−3; ****p < 1.0 × 10−4)

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