Fig. 2
Cell-type distributions of the samples included in the Mayo Clinic and MSBB. Mean neuronal (blue) and astrocytic proportion (red) for (a) AD affected brains and controls (bars indicate standard deviations). The numbers of participants for each group are shown below the x-axis. Distribution for additional clinical and pathological phenotypes reported for the MSBB: (b) CDR scores and (c) Braak staging. d Brain cell-type proportions (x-axis) plotted against the mean number of amyloid plaque (values > 0; y-axis). Standard errors were depicted in shaded area with LOESS smooth curve fitted to cell-type proportions derived from deconvolution. (**p < 0.01; ***p < 1.0 × 10−3; and ****p < 1.0 × 10−4)