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Fig. 3 | Genome Medicine

Fig. 3

From: Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

Fig. 3

Relationship between DNA methylation and gene expression. a Comparison of differentially methylated genes and differentially expressed genes. Genes were considered differentially methylated if at least one promoter CpG site was significantly differentially methylated. b Correlation between gene expression and its promoter methylation. Correlations were calculated using all 16,206 genes, 2215 differentially expressed (DE) genes, 3364 differentially methylated (DM) genes, or 287 both DE and DM genes. The vertical axis shows the percentage of negatively correlated genes (green), positively correlated genes (red), and genes with both negative and positive correlation (black). c Correlation between promoter methylation and other gene expression. This analysis focused on the promoter methylation of 287 DM and DE genes (columns) and the gene expression of 2215 DE genes (rows). Positive and negative correlations are shown in red and green, respectively

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