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Fig. 4 | Genome Medicine

Fig. 4

From: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Fig. 4

DNA methylation and expression CoGAPS patterns demonstrate delayed onset of epigenetic changes in acquired resistance. CoGAPS patterns for gene expression (top) and DNA methylation (bottom) of patterns associated with acquired cetuximab resistance in SCC25 cetuximab generations (red) relative to PBS generations (black). Vertical dashed line represents time at which patterns for SCC25 generation separated from pattern for PBS generations. The timing of methylation changes distinguishing cetuximab-resistant generations was delayed in DNA methylation relative to that of gene expression

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