Fig. 3From: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistanceDynamics of DNA methylation alterations and patterns in acquired cetuximab resistance. a Heatmap of DNA methylation values in 11 generations of SCC25 cells treated with PBS as control (black columns) and with 100Â nM of cetuximab (red columns) to acquire resistance. b Heatmap of DNA methylation values for genes selected by CoGAPS DNA methylation patterns analysis in the same SCC25 cetuximab and PBS generations. c CoGAPS patterns inferred from DNA methylation data over generations of PBS control (black lines) or treatment with 100Â nM of cetuximab (red lines)Back to article page