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Fig. 3 | Genome Medicine

Fig. 3

From: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Fig. 3

Dynamics of DNA methylation alterations and patterns in acquired cetuximab resistance. a Heatmap of DNA methylation values in 11 generations of SCC25 cells treated with PBS as control (black columns) and with 100 nM of cetuximab (red columns) to acquire resistance. b Heatmap of DNA methylation values for genes selected by CoGAPS DNA methylation patterns analysis in the same SCC25 cetuximab and PBS generations. c CoGAPS patterns inferred from DNA methylation data over generations of PBS control (black lines) or treatment with 100 nM of cetuximab (red lines)

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