Fig. 1

Characteristics of somatic mutations acquired in human ASCs of different tissues. a Relative contribution of the indicated mutation types to the point mutation spectrum for each tissue type. Bars depict the mean relative contribution of each mutation type over all ASCs per tissue type and error bars indicate the standard deviation. The total number of somatic point mutations per tissue is indicated. b Relative contribution of each indicated trinucleotide change to the three mutational signatures that were identified by NMF analysis of the somatic mutation catalogues of the ASCs. c Relative contribution of each mutational signature for each sample. d Heatmap showing the cosine similarity of the mutational signatures in b with the COSMIC signatures