Fig. 1

Alternative splicing event detection across 34 normal and cancer cell types. a Sashimi plots visualizing a specific splice site for each of five major types of AS events. The constitutive splicing isoform is shown in the upper track in yellow and the alternative splicing isoform is shown in the lower track. Percentage spliced in (ψ) value is shown on the right side. SE skipped exon, MXE mutual exclusive exon, RI retained intron, A5SS alternative 5′-end splice site, A3SS alternative 3′-end splice site. b The distribution of ψ-value in five types of AS events identified by the MISO tool. Cutoff values are 0.2 for SE and A3SS and 0.8 for RI and A5SS; for MXE, ψ values in the range 0–0.2 and 0.8–1 were used for two exons mutually exclusive to each other. c Total number of AS events for each of five types at the defined ψ value cutoffs. d Five types of AS events clustered in 34 cell types showing the difference between normal and cancer cell types. FB fibroblast