Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

Table 2 Enrichment of AD heritability at variants within SPI1, Spdef, RUNX and no-motif-containing microglia ATAC-seq peaks

Motif set	Enrichment	Enrichment P value	Corrected P value
SPI1	16.28	1.10 × 10⁻³	4.39 × 10^{− 3}
Spdef	19.92	9.93 × 10^{− 3}	0.040
No-motif	20.27	0.042	0.168
RUNX	14.09	0.103	0.412

AD heritability was partitioned by transcription factor motif-containing ATAC-seq peaks using LDscore regression [12]. AD heritability was significantly enriched (after correcting for multiple testing) at SPI1 and Spdef transcription factor motif-containing ATAC-seq peaks but not the RUNX or no motif sets
AD Alzheimer’s disease

ISSN: 1756-994X