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Table 1 Enrichment of AD heritability at variants within EGR1, CEBPA, MEF2A, SPI1 and no-motif-containing macrophage DNase hypersensitivity sites

From: Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

DHS motif set

Enrichment

Enrichment P value

Corrected P value

EGR1

14.481

1.03 × 10− 4

5.14 × 10− 4

CEBPA

9.716

6.86 × 10− 4

3.43 × 10−3

SPI1

8.933

2.43 × 10−3

0.012

MEF2A

19.222

4.46 × 10−3

0.022

No-motif

7.661

0.125

0.623

  1. AD heritability was partitioned by transcription factor motif-containing DNase hypersensitivity sites using LDscore regression [12]. AD heritability was significantly enriched (after correcting for multiple testing) at all four transcription factor motif-containing DNase hypersensitivity sites but not the no-motif set
  2. AD Alzheimer’s disease
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Genome Medicine

ISSN: 1756-994X

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