Fig. 2

Overlap between genome-wide significant AD risk variants and open chromatin sites identified in monocyte, macrophage and microglia samples. AD risk variants and 10,000 sets of matched SNPs were intersected with open chromatin regions. z scores were calculated for the AD risk variants set for each tissue type. The x-axis is the z score and the y-axis the cell type. Box plots indicate the distribution of overlap from the 10,000 background matched SNP sets. Red circles are the z scores for the AD risk variants set. P values were calculated from the observed overlap of the 10,000 background matched SNP sets. P values have been corrected for 37 tests. AD Alzheimer’s disease, SNP single-nucleotide polymorphism. ***P < 0.005, **P < 0.01, *P < 0.05